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Consideration should be disposed to victimisation a lower berth acid of zolpidem when a potent CYP3A4 inhibitor and zolpidem are given jointly [see CLINICAL PHARMACOLOGY]. The chase adverse reactions receive been identified during postapproval employment of AMBIEN CR. Because these reactions are reported voluntarily from a universe of incertain size, it is not e'er imaginable to dependably reckon their absolute frequency or install a causal family relationship to drug pic. In the 6-calendar month tribulation evaluating AMBIEN CR 12.5 mg, the harmful chemical reaction visibility was logical with that reported in short-condition trials, demur for a higher incidence of anxiety (6.3% for AMBIEN CR versus 2.6% for placebo).