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Note: Within the US, nutraceuticals are marketed beneath the Dietary Supplement and Health Education Act of 1994 (DSHEA). Consequently, scientific information supporting claimed profit(s) are usually not always obtainable for nutraceuticals as they're for traditional pharmaceuticals since nutraceuticals are usually not regulated as drugs. Consumers also needs to note that rigid high quality management requirements are usually not required for nutraceuticals and substantial variability can happen in both the potency and the purity of these merchandise. Monographs on nutraceuticals are included in CP when reliable clinical knowledge can be found. The information offered below is condensed from the most effective clinical knowledge we may find. Description: Huperzia serrata is a membership moss that has been used for centuries in Chinese medicine. It comprises an alkaloid often called huperzine A (HupA). HupA has been reported to be effective in treating reminiscence loss associated with Alzheimer's and other types of dementia. In China, huperzine A is called "Qian Ceng Ta".

8482;. Other Huperzine A merchandise are additionally available. Actions: the alkaloid HupA binds very tightly to and inhibits acetylcholinesterase (AChE), thereby potentiating the actions of endogenous acetylcholine; binding of HupA to the enzyme is reversible; some analogs of HupA are much more potent inhibitors of AChE; in rat mind cortex experiments, concentrations of acetylcholine, dopamine, and norepinephrine all increased after administration of HupA (Zhu XD et al. 1995); different agents authorized for treating Alzheimer's dementia (e.g., donepezil, tacrine) also inhibit AChE. 8482; as a nutritional complement to adults in their 50s, 60s, and 70s who're experiencing reminiscence loss; some investigators have tested the drug as a remedy of patients exposed to nerve gasoline. Contraindications/Precautions: Note: Nutraceuticals ought to be used cautiously in younger youngsters and pregnant females; this herb should not be used during pregnancy or in patients with hypertension. Drug Interactions: unclear at the moment; since this herb potentiates acetylcholine, it would seem illogical to make use of medicine with central anticholinergic properties concomitantly (e.g., benztropine, trihexyphenidyl). Also, concomitant use with other acetylcholinesterase inhibitors (e.g., tacrine, donepezil) cannot be recommended at this time; it is unknown if increases in acetylcholine related unintended effects can be potentiated by such mixtures. Adverse Reactions: Unclear at this time; nausea, dyspepsia, and dizziness have been reported in limited clinical trials. Dosage: unclear presently. 8212;400 mcg PO per day, given in divided doses. Bioequivalence Issues: Note: Potency for nutraceutical products can differ substantially from producer to producer; customers mustn't confuse the raw product (i.e., the moss) with the alkaloid; different compounds in the moss might be toxic. Some merchandise may contain standardized or purified HupA extracts. •animal knowledge: Zhu XD et al. •animal data: Tang XC et al. •clinical trial (Chinese): Xu SS et al. •clinical trial (Chinese): Zhang RW et al. •review: Hanin I et al.

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