Results: within The Bold-fMRI Procedure > 자유게시판

Purpose: To elucidate the totally different neuromechanisms of subjects with strabismic and anisometropic amblyopia compared with normal vision topics using blood oxygen stage-dependent functional magnetic resonance imaging (Bold-fMRI) and pattern-reversal visible evoked potential (PR-VEP). Methods: Fifty-three subjects, age vary seven to 12 years, diagnosed with strabismic amblyopia (17 instances), anisometropic amblyopia (20 cases), and normal imaginative and BloodVitals SPO2 prescient (16 cases), were examined using the Bold-fMRI and PR-VEP of UTAS-E3000 methods. Cortical activation by binocular viewing of reversal checkerboard patterns was examined in terms of the calcarine region of interest (ROI)-based and spatial frequency-dependent analysis. The correlation of cortical activation in fMRI and the P100 amplitude in VEP were analyzed utilizing the SPSS 12.Zero software program bundle. Results: In the Bold-fMRI process, BloodVitals SPO2 reduced areas and decreased activation ranges were found in Brodmann space (BA) 17 and different extrastriate areas in topics with amblyopia compared with the conventional vision group. On the whole, the diminished areas mainly resided within the striate visual cortex in topics with anisometropic amblyopia.

In subjects with strabismic amblyopia, a more important cortical impairment was present in bilateral BA 18 and BA 19 than that in subjects with anisometropic amblyopia. The activation by high-spatial-frequency stimuli was reduced in bilateral BA 18 and 19 as well as BA 17 in subjects with anisometropic amblyopia, whereas the activation was mainly lowered in BA 18 and BA 19 in subjects with strabismic amblyopia. These findings have been additional confirmed by the ROI-based evaluation of BA 17. During spatial frequency-dependent VEP detection, BloodVitals SPO2 topics with anisometropic amblyopia had decreased sensitivity for BloodVitals SPO2 high spatial frequency in comparison with subjects with strabismic amblyopia. The cortical activation in fMRI with the calcarine ROI-based evaluation of BA 17 was considerably correlated with the P100 amplitude in VEP recording. Conclusions: This examine instructed that several types of amblyopia had totally different cortical responses and combos of spatial frequency-dependent Bold-fMRI with PR-VEP might differentiate among numerous sorts of amblyopia according to the totally different cortical responses. This research can supply new methods for amblyopia neurology examine.

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